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All infants had microcephaly and head computed tomography findings compatible with congenital Zika syndrome.

Zika Ig M antibody was detected in cerebrospinal fluid samples of 23 infants.

To report the echocardiographic evaluation of 103 infants with presumed congenital Zika syndrome.

An observational retrospective study was performed at Instituto de Medicina Integral Prof. 103 infants with presumed congenital Zika syndrome.

Several immune mediators were specifically higher in ZIKV-infected patients, and levels of interleukin 10, interferon gamma-induced protein 10 (IP-10), and hepatocyte growth factor differentiated between patients with or without neurological complications.

Interestingly, higher levels of interleukin 22, monocyte chemoattractant protein 1, TNF-?

14/103 (13.5%) echocardiograms were compatible with congenital heart disease: 5 with an ostium secundum atrial septal defect, 8 had a hemodynamically insignificant small apical muscular ventricular septal defect and one infant with dyspnea had a large membranous ventricular septal defect.

However the types of defects noted were septal defects, a proportion of which would not be hemodynamically significant.

The current Zika virus (ZIKV) epidemic is characterized by severe pathogenicity in both children and adults.

A 1 degrees C decrease of mean temperature was associated with a RR of 17.4% (95% CI: 11.2-27.0%); the effect was inversed for a 1 degrees C increase of mean temperature (RR= 0.457, 95% CI: 0.278-0.752).

Climate variables are important determinants of dengue incidence and provide insight into its short-term effects.However, the immature ZIKV contains a partially ordered capsid protein shell that is less prominent in other immature flaviviruses.



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